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Hector Santiago (3-1, 2.78 ERA 25K) - Mike Pelfrey (0-2, 5.02 ERA 4K)

Santiago is off to a solid start his year and is coming off a quality start against the A's on Wednesday. He went six innings, allowing three runs on four hits and three walks. Santiago has had success against his former organization, going 4-1 with a 1.40 ERA in six starts. Pelfrey is still searching for his first victory of the season, and has yet to pitch more than 5 1/3 innings in a start. He reached that mark last time out, allowing three earned runs on five hits in a 6-1 loss to the Royals. He has rough numbers gainst the Twins, posting a 6.88 ERA against them in four starts.